Specific gene linked to suicidal behaviour
By Catherine Walker
Evidence that a specific gene is linked to suicidal behaviour a new UK study has found. Researchers believe this study may help experts to target the gene in future efforts for prevention.
Previous research has suggested that the gene for brain-derived neurotrophic factor (BDNF) is implicated in suicidal behaviour. BDNF is involved in the development of the nervous system.
The results from eleven previous studies were pooled along with their own research data. This involved people with schizophrenia and the researchers confirmed that among people with a psychiatric diagnosis, those with one variation of the gene had a higher risk of suicidal behaviour when compared to those with a different variation.
The research is published in the International Journal of Neuropsychopharmacology.
The data from 3,352 people, of whom 1,202 had a history of suicidal behaviour was reviewed by the investigators.
Dr. James Kennedy, director of the Centre for Addiction and Mental Health Neuroscience Research Department, said ‘Our findings may lead to the testing and development of treatments that target this gene in order to help prevent suicide.’
‘In future, if other researchers can replicate and extend our findings, then genetic testing may be possible to help identify people at increased risk for suicide,’ Kennedy added.
It may also be possible to develop a compound to increase BDNF functioning said Dr. Kennedy.
The researchers noted that about 90% of people who have died by suicide have at least one mental health disorder. In the current study the participants had schizophrenia, bipolar disorder, depression or general mood disorders.
Investigators compared the genotypes of people who had attempted or completed suicide with those who were non-suicidal.
Dr. Kennedy says ‘Our findings provide a small piece of the puzzle on what causes suicidal behaviour.’
‘When assessing a person’s suicide risk, it is also important to consider environmental risk factors, such as early childhood or recent trauma, the use of addictive drugs or medication and other factors,’ Kennedy concluded.
Source: Centre for Addiction and Mental Health
